This course builds on basic anatomy and physiology acquired in the undergraduate and graduate study of pathophysiology. The development of an advanced understanding of pathophysiologic mechanisms of human health disorders serve as the underpinnings for clinical assessment, decision making, management, and evaluation of the patient’s response to treatment. Diagnostic reasoning that facilitates the clustering of signs and symptoms leading to a diagnosis, followed by evaluation of the treatment, are foundational to the course. This course requires the integration of the pathophysiologic mechanisms of signs, symptoms, diagnoses, and treatment with clinical testing, which include laboratory and radiological studies.